GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | EFCAB5 | chr17:28256874-28435469:+ | -0.6 | -11.36 | 1.24E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | GIT1 | chr17:27900487-27916610:- | -0.28 | -6.64 | 8.47E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | LRRC37B2 | chr17:28903483-28992715:+ | -0.18 | -3.94 | 9.46E-5 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | SSH2 | chr17:27952965-28257018:- | -0.35 | -7.82 | 3.51E-14 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | TP53I13 | chr17:27895739-27900174:+ | -0.2 | -5.48 | 6.87E-8 | Coffee consumption (cups per day) |
| THCA | cis | rs12960119 | 1 | rs6508409 | chr18:23617290 | SS18 | chr18:23596219-23671164:- | 0.26 | 3.36 | 0.000841 | Rhegmatogenous retinal detachment |
| THCA | cis | rs7246657 | 1 | rs6508710 | chr19:37749886 | ZNF607 | chr19:38187276-38210691:- | -0.21 | -3.63 | 0.000311 | Coronary artery calcification |
| THCA | cis | rs4803468 | 1 | rs6508977 | chr19:41909346 | B3GNT8 | chr19:41931265-41934635:- | -0.36 | -8.3 | 1.05E-15 | Height |
| THCA | cis | rs4803468 | 1 | rs6508977 | chr19:41909346 | EXOSC5 | chr19:41892278-41903256:- | -0.1 | -3.4 | 0.000731 | Height |
| THCA | cis | rs10411161 | 1 | rs6509581 | chr19:52363882 | ZNF577 | chr19:52359056-52394145:- | -0.24 | -5.66 | 2.56E-8 | Breast cancer |
| THCA | cis | rs10411161 | 1 | rs6509581 | chr19:52363882 | ZNF649 | chr19:52392489-52408247:- | -0.18 | -3.76 | 0.000194 | Breast cancer |
| THCA | cis | rs8113308 | 1 | rs6509600 | chr19:52442589 | ZNF577 | chr19:52359056-52394145:- | -0.21 | -4.6 | 5.38E-6 | Survival in endocrine treated breast cancer (estrogen-receptor positive) |
| THCA | cis | rs6509701 | 1 | rs6509701 | chr19:53384185 | ZNF320 | chr19:53367119-53400946:- | -0.23 | -5.51 | 5.94E-8 | Psychosis in Alzheimer's disease |
| THCA | cis | rs6509701 | 1 | rs6509701 | chr19:53384185 | ZNF468 | chr19:53341786-53360902:- | -0.16 | -4.37 | 1.55E-5 | Psychosis in Alzheimer's disease |
| THCA | cis | rs10416265 | 1 | rs6510348 | chr19:33601946 | GPATCH1 | chr19:33571786-33621318:+ | 0.36 | 8.74 | 3.94E-17 | Bone properties (heel) |